The Infrastructure Innovation for Biological Research (IIBR) solicitation supports new and innovative research in biological informatics, instrumentation and associated methods, as well as multidisciplinary approaches to these broad themes that address needs in basic biological research. These awards support pioneering approaches that develop de novo infrastructure, significantly redesign existing infrastructure, or apply existing infrastructure in novel ways. Activities must demonstrate the potential to advance or transform research in biology as supported by the Directorate for Biological Sciences at the National Science Foundation (https://nsf.gov/bio).